In-Kyu Lee Selected Research

Thioctic Acid (Lipoic Acid)

12/2014	Alpha lipoic acid induces hepatic fibroblast growth factor 21 expression via up-regulation of CREBH.
6/2014	Alpha-lipoic acid protects against cisplatin-induced ototoxicity via the regulation of MAPKs and proinflammatory cytokines.
1/2014	Physiological effect and therapeutic application of alpha lipoic acid.
2/2012	α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway.
1/2012	Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.
8/2011	Adenosine monophosphate kinase activator α-lipoic acid: A promising therapeutic agent for metabolic syndrome?
1/2011	Effects of alpha-lipoic Acid on body weight in obese subjects.
11/2010	α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization.
3/2010	Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway.
11/2006	Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery.

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In-Kyu Lee Research Topics

Disease

37	Type 2 Diabetes Mellitus (MODY) 10/2021 - 07/2002
32	Neoplasms (Cancer) 01/2022 - 02/2008
27	Inflammation (Inflammations) 01/2022 - 05/2004
22	Obesity 05/2022 - 07/2004
22	Insulin Resistance 01/2019 - 03/2007
18	Atherosclerosis 03/2022 - 05/2004
16	Fibrosis (Cirrhosis) 01/2018 - 03/2004
11	Fatty Liver 05/2022 - 09/2009
11	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 12/2005
11	Mitochondrial Diseases (Mitochondrial Disease) 01/2022 - 02/2012
10	Vascular Calcification 03/2022 - 04/2010
10	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2017 - 09/2009
9	Body Weight (Weight, Body) 05/2022 - 03/2004
9	Metabolic Diseases (Metabolic Disease) 01/2022 - 04/2010
9	Hypoxia (Hypoxemia) 01/2021 - 10/2008
7	Hyperglycemia 01/2019 - 02/2007
7	Hyperplasia 10/2015 - 11/2006
6	Non-alcoholic Fatty Liver Disease 09/2022 - 12/2010
6	Ototoxicity 01/2022 - 06/2014
6	Vascular System Injuries 03/2015 - 06/2002
5	Hearing Loss (Hearing Impairment) 09/2021 - 06/2014
5	Anaplastic Thyroid Carcinoma 01/2021 - 11/2015
5	Thrombosis (Thrombus) 05/2019 - 10/2009
5	Hepatocellular Carcinoma (Hepatoma) 01/2017 - 02/2010
4	Neuroinflammatory Diseases 01/2019 - 02/2015
4	Hypersensitivity (Allergy) 01/2019 - 10/2015
4	Hyperlipidemias (Hyperlipidemia) 01/2019 - 09/2009
4	Vascular Remodeling 10/2015 - 12/2005
4	Vascular Diseases (Vascular Disease) 10/2014 - 08/2003
4	Hypertension (High Blood Pressure) 02/2014 - 01/2011
3	Nervous System Diseases (Neurological Disorders) 01/2022 - 09/2016
3	Acute Kidney Injury (Acute Renal Failure) 01/2021 - 01/2017
3	Diabetic Neuropathies (Diabetic Neuropathy) 01/2021 - 03/2016
3	Bone Resorption 01/2021 - 11/2012
3	Thyroid Neoplasms (Thyroid Cancer) 11/2020 - 07/2012

Drug/Important Bio-Agent (IBA)

26	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 07/2002
22	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2009
15	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 04/2009
13	Pharmaceutical PreparationsIBA 01/2022 - 09/2009
12	AntioxidantsIBA 06/2020 - 02/2003
11	LipidsIBA 01/2021 - 02/2003
11	Estrogens (Estrogen)FDA Link 01/2021 - 01/2012
11	Insulin (Novolin)FDA Link 01/2021 - 09/2009
11	Pyruvic Acid (Pyruvate)IBA 01/2021 - 11/2012
11	Thioctic Acid (Lipoic Acid)IBA 12/2014 - 07/2004
10	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 03/2007
9	CytokinesIBA 01/2022 - 11/2006
9	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2021 - 06/2014
8	Phosphotransferases (Kinase)IBA 01/2021 - 08/2011
7	Cisplatin (Platino)FDA LinkGeneric 01/2022 - 11/2012
7	EnzymesIBA 01/2022 - 07/2004
7	Orphan Nuclear ReceptorsIBA 01/2021 - 02/2007
7	GSK5182IBA 12/2019 - 01/2012
7	pyruvate dehydrogenase kinase 4IBA 03/2019 - 01/2012
7	Plasminogen Activator Inhibitor 1IBA 01/2012 - 09/2009
6	CalciumIBA 03/2022 - 01/2013
6	Lactic Acid (Lactate)FDA LinkGeneric 05/2021 - 10/2015
6	Therapeutic UsesIBA 01/2021 - 11/2013
6	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 02/2008
6	ClusterinIBA 01/2018 - 10/2009
5	Biological ProductsIBA 09/2022 - 01/2017
5	Hormones (Hormone)IBA 01/2022 - 01/2012
5	Oxygen (Dioxygen)IBA 11/2021 - 10/2008
5	Metformin (Glucophage)FDA LinkGeneric 10/2018 - 02/2008
5	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2018 - 01/2012
5	AMP-Activated Protein KinasesIBA 09/2013 - 07/2004
4	NAD (NADH)IBA 01/2021 - 04/2009
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2020 - 01/2013
4	sodium-iodide symporter (sodium iodide symporter)IBA 01/2019 - 11/2015
4	Methionine (L-Methionine)FDA Link 01/2017 - 09/2009
4	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 10/2016 - 02/2012
4	Messenger RNA (mRNA)IBA 05/2015 - 09/2009
4	Fibronectins (Fibronectin)IBA 07/2014 - 10/2009
4	quinone (benzoquinone)IBA 02/2014 - 04/2009
4	Collagen Type I (Type I Collagen)IBA 02/2012 - 10/2009
4	Transforming Growth Factor beta (TGF-beta)IBA 03/2010 - 03/2004
4	NF-kappa B (NF-kB)IBA 03/2007 - 11/2006
3	IronIBA 01/2022 - 05/2006
3	Persistent Organic PollutantsIBA 01/2022 - 03/2007
3	Anti-Bacterial Agents (Antibiotics)IBA 09/2021 - 12/2013
3	TunicamycinIBA 01/2021 - 02/2010
3	Lipocalin-2IBA 01/2021 - 01/2019
3	AcidsIBA 01/2021 - 01/2016
3	GoldIBA 01/2021 - 01/2017
3	Phosphates (Orthophosphate)IBA 12/2020 - 02/2012
3	Glutamine (L-Glutamine)FDA Link 11/2020 - 03/2015
3	Sterol Regulatory Element Binding Protein 1IBA 12/2019 - 05/2013
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2019 - 05/2004
3	fibroblast growth factor 21IBA 01/2019 - 08/2014
3	LigandsIBA 01/2019 - 06/2007
3	Sitagliptin Phosphate (Januvia)FDA Link 10/2018 - 07/2014
3	CreatinineIBA 01/2018 - 08/2015
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 04/2012
3	Polychlorinated Biphenyls (PCBs)IBA 10/2017 - 03/2007
3	Triglycerides (Triacylglycerol)IBA 01/2017 - 12/2011

Therapy/Procedure

18	Therapeutics 01/2022 - 10/2008
5	Glycemic Control 10/2021 - 01/2015
3	Precision Medicine 01/2022 - 10/2015
3	Drug Therapy (Chemotherapy) 05/2021 - 11/2012
3	Stents 11/2020 - 12/2009